[The effectiveness of ranitidine in non-ulcer dyspepsia (functional dyspepsia) in comparison with an antacid] Medizinische Klinik (Munich, Germany : 1983) [Med Klin (Munich)] Journal article | | Title | [The effectiveness of ranitidine in non-ulcer dyspepsia (functional dyspepsia) in comparison with an antacid] | | Author(s) | Hotz J, Plein K, Bunke R | | Institution | Klinik für Gastroenterologie, Allgemeines Krankenhaus Celle. | | Source | Med Klin (Munich) 1994 Feb 15; 89(2):73-80, 107. | | MeSH | Adolescent
Adult
Aged
Aged, 80 and over
Aluminum Hydroxide
Antacids
Comparative Study
Drug Combinations
Dyspepsia
English Abstract
Esophagitis, Peptic
Female
Humans
Magnesium Hydroxide
Male
Middle Aged
Ranitidine
Research Support, Non-U.S. Gov't
Silicic Acid
| | Abstract | BACKGROUND: It is generally accepted that functional dyspepsia is caused by heterogeneous pathogenetic factors. From the clinical point of view acid-related symptoms as heartburn, acid regurgitation and epigastric pain (acid-type) can be separated from general dyspeptic symptoms as predominant fullness, nausea/vomiting (dysmotility-type).
PATIENTS AND METHODS: In the present study, the influence of a four-week-treatment with ranitidine (twice 150/d, n = 346) in comparison with an antacid (40 mmol/d, n = 340) on the severity and course of symptoms in patients suffering from an acid-related functional dyspepsia was investigated.
RESULTS: With ranitidine, acid-related as well as general dyspeptic symptoms disappeared in a significantly higher percentage after two and four weeks compared with antacid. Complete disappearance of symptoms was documented with ranitidine after two weeks in 37% and after four weeks in 66% compared with antacid in 13% and 30% respectively (p < 0.005). Patients with severe symptoms, history of ulcer and long-term dyspepsia and slight endoscopic changes in the upper gastrointestinal tract showed a significant faster and more distinct response. Both kinds of treatment were well tolerated.
CONCLUSION: It is concluded that in acid-related functional dyspepsia ranitidine is superior to antacid in relieving symptoms. Therefore, a probative treatment with ranitidine up to four weeks is recommended as a practical therapeutic alternative in this syndrome. | | Language | ger | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
| | PubMed ID | 8164599 |
|
|
| |
Advertise on this site.
| | |
|
